I would not: Keychain is something you take with you, I treat it as my password database, just like 1Password/LassPass/whatever else folks use these days, because that’s exactly what it is. It’s replicated to million places and snapshotted regularly so I don’t really envision a realistic scenario where information would be lost.
And yet, you can simulate that if you really wanted to – once you install duplicacy do not approve its request to access keychain and make sure you can get all necessary credentials to configure it manually yourself as if you not only lost your Mac, but all other iOS/iPadOS/etc devices and access to your iCloud account they were logged into…
On a separate note, if loss of keychain is a concern – I would print credentials and put that paper into a bank deposit box. But that would be way overkill for most people…